External factors
| External factors: |
Gamma-tocotrienol |
| Experiment: |
Flow cytometry//qRT-PCR//SA-β-gal activity assay |
| Description: |
γ-Tocotrienol c-Tocotrienol significantly decreased (p,0.05) the percentage of senescent HDFs in the G0/G1phase. In contrast,c-tocotrienol significantly increased (p,0.05) the percentage of senescent HDFs in the G2/M phase.However,c-tocotrienol produced significant downregulations of MMP1 mRNA expression in pre-senescent and senescent HDFs compared to untreated cells (p,0.05).c-Tocotrienol produced significant(p,0.05) upregulations of COL1A1 in young, pre-senescent,and senescent HDFs. c-Tocotrienol also significantly upregulated ELN mRNA in young and senescent HDFs. c-Tocotrienol significantly downregulated IL6, CCND1 and RB1 mRNA expression in senescent HDFs (p,0.05)..The incubation of senescent cells with 70 mM c-tocotrienol did not alter the percentage of SA-β-gal-positive cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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