External factors
| External factors: |
High glucose |
| Phenotype: |
Type 2 diabetes mellitus |
| Cell name: |
Endothelial cell |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
Accordingly, the percentage of senescent EC reached a significant level after 48 h of treatment with hGluc (44.271.31% vs. 18.171.52% in Ctr, Po0.01). SA β-gal positive cells in samples co-treated with EgtthGluc were 28.371.22% vs. 44.271.31% in hGluc (Po0.01). Moreover, microscopy examination revealed that the hGluc senescent EC become large and with more spindle-shaped morphology. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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