External factors
| External factors: |
Radiation |
| Phenotype: |
Squamous cell carcinoma |
| Cell name: |
HNSCC,FaDu-DN,FaDu-EBV,FaDu-HE |
| Experiment: |
SA-β-gal activity assay//Flow cytometry//Western blot |
| Description: |
In the first 12 hours after radiation treatment all the cell lines showed a similar pattern of cell cycle changes – reduction of G1 phase and an increase of S and G2 phases. After irradiation, at 48h and 72h FaDu-HPV (p<0.01), FaDu-EBV (p<0.05) and FaDu-HE (p<0.001) cell lines had significantly higher percentages of senescent cells in comparison with respective FaDu-DN cell line at indicated time points. Our samples displayed reduced AKT and ERK activities accompanied by elevated p21 after radiation in agreement with upregulated senescence level in FaDu HPV/EBV cell lines. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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