External factors
| External factors: |
Chromosome 5 |
| Experiment: |
Telomerase activity assay//SA-β-gal activity assay |
| Description: |
Assay of telomerase activity:A2058#5 clone showed a 90% decrease in telomerase activity，this indicates that normal human chromosome 5, at its physiological level, suppressed hTERT expression and telomerase activity in A2058 cells. SA-β-gal activity assay:A2058#5S clones presented with significant morphological changes compared to parental A2058 cells, characterized by an elongated and somewhat enlarged and flat shape,s, introduction of chromosome 5 greatly reduced the growth rate of A2058 cells. Additionally, the majority of A2058#5S clones entered cellular senescence at around 20 PDs, as determined by SA-b-Gal staining. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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