External factors
| External factors: |
Platinum(II)phenanthroimidazole G-quadruplex ligand |
| Cell name: |
A549,HuH-7,MRC-5 |
| Experiment: |
Cell cycle analysis |
| Description: |
However treatment with 2.0*PIP induced a mild but significant G1 arrest (p<0.001) and reduced the number of cells in S phase (p<0.01) in telomerase positive A549 cells.As early as 7 days after ligand treat-ment, a concentration-dependent increase in senescent cells staining positive for β-galactosidase in telomerase positive A549 and Huh7 cancer cells was observed, as compared to the DMSO treated control cells. Treatment of normal primary MRC5 cells also led to an increase in cells staining positive for β-galactosidase and to an increase in the number of cells with a broad,flattened morphology. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793