External factors
| External factors: |
Hyaluronan |
| Category: |
Chemical compounds |
| Experiment: |
Flow cytometry//SA-β-gal activity assay |
| Description: |
MSCs cultivated in L-HA either at 0.16% or 0.5% concentration showed a significant reduction in cycling cells compared with the controls, and this was accompanied by a concomitant increase in quiescent cells.Flow cytometry analysis of MSC cultures evidenced that all the experimental conditions, but 0.16% HCC, modified the pattern of cell cycle profiles with respect to control conditions.The apoptosis process was not affected by incubation with the different HA mixtures.while enescence was noticeably reduced , as detected by annexin V flow cytometry analysis and in situ β-galactosidase assay.The number of MSC clones was reduced after incubation with all the analyzed HA mixtures. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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