External factors
| External factors: |
Trabectedin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
DNA content histograms of SW872 (left) and U2OS (right) 24 and 48 hrs after treatment (10 nmol/l trabectedin). In both cell lines, trabectedin caused a marked G2/M arrest after 24 hrs, which was strongly enhanced by additional hyperthermia (upper row).treatment with additional hyperthermia prolonged trabectedin‐induced cell cycle arrest in both investigated cell lines (lower row). Hyperthermia alone caused no significant alterations in cell cycle distributions (data not shown).Particularly U2OS—instead of undergoing apoptosis—showed a strong senescence response and a heat‐dependent continuously increasing number of senescent cells over 72 hrs (data not shown) to 144 hrs. In comparison, SW872, which preferentially underwent apoptosis, showed no detectable induction of senescence. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793