External factors
| External factors: |
Curcumin |
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Cell name: |
HROC257 T0 M1,HROC50 T1 M5,HROC60,HROC183 T0 M2 |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
By contrast, all substances and combinations caused senescence in HROC tumor cells with a tendency towards higher β-galactosidase activity after single treatment. Numbers of cells in G0/G1 phase decreased (HROC257 T0 M1 > HROC50 T1 M5 > HROC60 > HROC183 T0 M2; a representative example shows Curcumin/Gemcitabine treated HROC257 T0 M1 (IDOhigh) cells; sub-G1 defines dead cells). The best antiproliferative effect was inducible in HROC183 T0 M2(IDOlow) cells after Indoximod/Curcumin treatment . Percentages of cells in S-phase were 17 % ± 9 % versus 33 % ± 11 % . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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