External factors
| External factors: |
PCO-rHDL |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
However, PCO in solvent dose-dependently inhibited cellular senescence up to 65% and 70% at 9 and 46 ?M (final), respectively, along with an increase in cell number, suggesting that PCO had anti-senescent and cell proliferation effects (photos c and d). Moreover, PCO-rHDL showed a stronger anti-aging effect and greater cellular proliferation in a dose-dependent manner. Compared to the PBS control, PCO-rHDL-treated cells (photos f and g) showed 68% and 80% reduction of SA-β-gal positive cells, whereas rHDL-treated cells (photo e) showed 52% reduction. PCO-rHDL also showed a cell proliferation effect of up to 1.9-fold and 1.6-fold for (1:5)-rHDL and (1:1)-rHDL, respectively, compared to rHDL alone (photo e). |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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