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Aging Overview

External factors

External factors: Tamoxifen
Aging type: Accelerate
Aging characteristic:
Category: Chemical compounds
Phenotype: Aging
Experimental category: L
Tissue type: --
Cell name: HUVEC
PMID: 18203850
Experiment: SA-β-gal activity assay//Annexin V binding assay
Description: When HUVECs were exposed to NC, tamoxifen-induced cell senescence increased about fourfold, whereas 3-MA affected senescence only marginally. In contrast, exposure of HUVECs to GC alone resulted in a greater than fivefold increase in the proportion of senescent cells, and the presence of 3-MA led to a significant attenuation of development of premature senescence.



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Regulatory pathway: --
R-EF-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.




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