External factors
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experiment: |
SA-β-gal activity assay//Flow cytometry//Cell morphological analysis//Knockdown |
| Description: |
Moreover, although all three MAPK inhibitors did not greatly influence cell cycle distribution of unstressed and irradiated cells, p53- and p21-deficient cells rescued by U0126 from γIR-induced apoptosis showed an enlarged and flattened morphology, exhibiting increased senescence-associated β-galactosidase (SA-β-Gal) activities.Remarkably, these senescence markers were even evident when checkpoint-deficient and wild-type HCT116 cells were treated solely with U0126. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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