External factors
| External factors: |
Metformin |
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Experiment: |
Cell morphological analysis |
| Description: |
We determined that 1 mM metformin proved to be a threshold concentration at which impaired cell proliferation was evident at 72 hours, Heterochromatic nuclei were observed in metformin treated cells, indicative of senescence in cells previously exposed to 1 mM metformin. Morphologically, cells exposed to metformin are enlarged and flattened, consistent with induction of stress-induced senescence. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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