External factors
| External factors: |
BET inhibitor JQ1 |
| Category: |
Chemical compounds |
| Phenotype: |
T-cell lymphoma |
| Cell name: |
MyLa,SeAx,HuT 78,HH |
| Experiment: |
Flow cytometry//Cell morphological analysis |
| Description: |
JQ1 inhibited CTCL proliferation and induced cell cycle arrest.Following 24 h of treatment with JQ1, marked increase in G1 phase and reduced S phase were observed in all cell lines compared to untreated cells. Senescence induces morphological and flow cytometric changes like enlarged cells with a vacuole-rich cytoplasm resulting in increased forward/side scatter values [2]. R1 was defined as SSC (Side Scatter)low FSC (Forward Scatter)low region and R2 was defined as SSChigh FSChigh region in viable cells as previously described [10]. Treatment of MyLa cells with JQ1 increased the cell number in the R2 region and decreased that in the R1 region. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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