External factors
| External factors: |
Lidamycin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
We observed SA-β-gal expression, a senescence marker, at 72 h after lidamycin treatment. The treated cells showed phenotypic changes that resembled features of normal senescence, including enlarged and flattened morphology, increased granularity, vacuolization, and enhanced SA-β-gal- positive cells.Moreover, the induction of senescence-like phenotype in BEL-7402 cells was increased dose-dependently. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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