External factors
| Category: |
Chemical compounds |
| Phenotype: |
Hepatocellular carcinoma |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
In HepG2 cells, increased β-galactosidase staining relative to control cells occurred 72 h after treatment with C-1311. SA-β-gal-positive cells continued to increase, and after 144 h of C-1311 exposure, the entire population of HepG2 cells displayed SA-β-gal staining. In addition to increased SA-β-gal staining, these cells had an enlarged and flattened morphology typical of senescent cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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