External factors
| External factors: |
Hinokitiol |
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Tissue type: |
Tumor tissue |
| Cell name: |
A549,H1975,H1299,H3255,PC-9,PC-9-IR |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
The effect of hinokitiol on cellular senescence was assessed through SA-β-Gal staining, and we found that hinokitiol treatment (5 μM, 72 h) induced cellular senescence in H1975 cells and, more significantly, in human lung stromal fibroblasts.This result indicated that hinokitiol induced the accumulation of cancer cells in the S phase of the cell cycle. Interestingly, this effect on cell cycle distribution was not significantly observed in human lung stromal fibroblasts treated with hinokitiol. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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