External factors
| External factors: |
Cisplatin |
| Category: |
Chemical compounds |
| Experiment: |
Cell morphological analysis//SA-β-gal activity assay |
| Description: |
48h after exposure to cisplatin, all of the treated cells became larger and flatter, resembling the morphology of human fibroblasts undergoing senescence. After exposure to low doses of cisplatin, the percentage of SA-β-gal positive cells began to increase at 48 h post-exposure time and reached a peak at 72 h in SUNEl cells and 96 h in HT29 cells. Then the percentage of SA-β-gal positive cells stabilized, correlating to the time when cell growth arrest occurred. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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