External factors
| Category: |
Chemical compounds |
| Phenotype: |
Cervical cancer |
| Cell name: |
HeLa,SiHa,HaCaT |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
In HeLa and SiHa cells treated with PTX + CIS the percentage of SA-β? Gal(+) was significantly lower (22.9 ± 7.5% and 27.2 ± 5.4 %, respectively) which represents a 3.6 and 3-times lower diminution in relationship to senescence induced by CIS alone ( P < 0.001). In untreated control groups, the apoptotic index was ≤ 13. In contrast, in all treated groups, important levels of apoptosis were detected, because when HeLa and SiHa tumor cells were treated with PTX alone, the apoptotic indexes were 43.8 ± 4.4 and 46.2 ± 2.4 respectively ( P < 0.001 vs untreated group). |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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