External factors
| External factors: |
WS-CoQ10 |
| Category: |
Chemical compounds |
| Phenotype: |
Alzheimer's disease |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
After culturing PSAF for over 27 passages, cells with no supplementation of PTS or WS-CoQ10 started to exhibit a wide cellular morphology, a sudden decrease in growth, and a high percentage of cells that were positive for blue SA-β-galactosidase (SA-β-gal) stain, a marker of cellular senescence. Slightly fewer SA-β-gal positive cells were found in the PTS supplemented PSAF and PSAF cultured with WS-CoQ10 had the lowest percentage of SA-β-gal stained cells.ad the lowest percentage of SA-β-gal stained cells.In conjunction to these findings, decreased levels of MnSOD, p21, Rb, and p16Ink4A were found in WS-CoQ10 cultured PSAF compared to cells without supplementation . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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