External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Western blot//BrdU assay//RT-PCR |
| Description: |
C75 treatment of HSCs showed a marked ability to prevent the activation of the senescent phenotype indicated by higher levels of BrdU staining and low SA-β-gal activity . Senescent cells treated with C75 significantly reduced IL1A, IL1B and IL6 mRNA levels in HSCs.Significant inhibition of cell cycle inhibitors and SASP genes in RAS-induced senescent cells were observed after treatment with C75. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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