External factors
| External factors: |
Glucocorticoid |
| Category: |
Chemical compounds |
| Experiment: |
ELISA//qRT-PCR//Knockdown |
| Description: |
The proliferation rates of MSCs 4 weeks after being treated to block endogenous GCs were significantly higher than controls .Treatment with RU486 or GR siRNA significantly up-regulated the expression of telomerase mRNA . The telomere lengths of MSCs treated with RU486 were significantly longer than those in controls . The MSCs treated with GR siRNA also had relatively longer telomeres than those in controls, but the differences are marginally significant (p=0.0625). In addition, total SOD activity, which is a key antioxidant, was 30–40% higher in MSCs that had been treated with RU486 or GR siRNA than in controls and these differences were statistically significant. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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