External factors
| Category: |
Chemical compounds |
| Phenotype: |
Gastric cancer |
| Experiment: |
SA-β-gal activity assay//Western blot |
| Description: |
When MKN28 cells treated with two different doses of JQ1 for 3 days and the activity of SA-β-Gal was measured, we observed a dose-dependent increased number of SA-β-Gal-positive cells with enlarged and flattened shape. Consistently, the expression of p21, a senescence marker, was dramatically induced by different doses of JQ1 while the levels of Cyclin B1 were down-regulated in JQ1-treated MKN28 or SGC-7901 cells.Consistently, the expression of p21, a senescence marker, was dramatically induced by different doses of JQ1 while the levels of Cyclin B1 were down-regulated in JQ1-treated MKN28 or SGC-7901 cells. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793