External factors
| Category: |
Chemical compounds |
| Experiment: |
PI stainingng//ELISA |
| Description: |
L2-Cmu treatment in females did not adversely affect cardiac function, but instead restored diastolic function to more youthful levels.Importantly, late-life L2-Cmu treatment improved mean lifespan (P=0.023) and increased median lifespan by 9% (P=0.03) in females. Aging in females was characterized by a significant rise in IL-1β, IL-4, IL-5, IL-6, IL-10,IL-12(p40), IL-12(p70), IL-17, CXCL-10, CXCL-1, MIP-1α, MIP-2, and TNFα, but several of these cytokines and chemokines were restored to a more youthful level with mAb treatment. In contrast, only G-CSF, IL-6,and RANTES were elevated in old male plasma, but mAb treatment led to a marked increase in the majority of these markers. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793