External factors
| External factors: |
N-Acetylcysteine |
| Category: |
Chemical compounds |
| Cell name: |
Endothelial cell |
| Experiment: |
Flow cytometry//PCR//SA-β-gal activity assay//Telomerase activity assay |
| Description: |
Incubation with N-acetylcysteine starting from populationdoubling 26 prevented the increase in ROS formation and the reduction of intact mitochondrial DNA. Furthermore, the reduction of nuclear TERT activity was blocked by N-acetylcysteine. Moreover, N-acetylcysteine prevented the reduction in overall TERT activity during further passaging and delayed the onset of replicative senescence. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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