External factors
| Category: |
Chemical compounds |
| Cell name: |
LNCaP,PC-3,H1299,A549 |
| Experiment: |
SA-β-gal activity assay//Transwell assay//MTS assay |
| Description: |
JQ-101 suppressed LNCaP and H460 tumor cell growth in a dose-dependent manner.Transwell chamber assay system with matrigel coated on the top of an ECM-like membrane to prevent the transmigration of non-invasive cells. Exposure to JQ-101 significantly decreased invasion compared to vehicle control, producing a 3.5-fold reduction in PC3 cell invasion and a 4.2-fold reduction in A549 cells.In contrast,apoptosis was not observed in H1299 cells (data not shown);instead, JQ-101 treatment induced cell senescence in H1299cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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