External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Telomere length assay//Cell morphological analysis//Cell Cell proliferation assay |
| Description: |
SA-β-gal activity assay:Early passage chondrocytes incubated with sub-lethal doses of H2O2 (75–100 mM) showed characteristic features of senescence concerning morphology and positive β-galactosidase staining. Following treatment with sub-lethal doses of H2O2, a significant decrease of proliferation rate was detected in early. Determination of Telomere Length:correlated with cpd in both groups (p < 0.01). With prolonged H2O2 treatment, significant increase in telomere shortening occurred. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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