External factors
| External factors: |
Homocysteine |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Coculture of HUVECs with homocysteine resulted in an increase in percentage of SA-β-gal-positive cells with a maximum effects achieved at 4 μM . In the prolonged culture, the number of SA-β-gal-positive cells at 4μM progressively rose from ~5% at day 1 to 24% at day 7. Over the 7-day period in culture, homocysteine produced as much as about five-fold increase in the percentage of senescent endothelial cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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