External factors
| External factors: |
Urolithin A |
| Category: |
Chemical compounds |
| Experiment: |
qRT-PCR//Western blot |
| Description: |
Collagen mRNA expression was significantly increased in cells treated with 20 μM and 50 μM urolithin A, and mRNA expression of MMP-1 significantly decreased in a urolithin A dose-dependent manner.We found that type I collagen expression in urolithin A-treated cells was upregulated, while MMP-1 expression was significantly downregulated. After a 5-day treatment with urolithin A, the intracellular ROS level was significantly reduced., suggesting that urolithin A attenuated ROS in senescent cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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