External factors
| Category: |
Chemical compounds |
| Phenotype: |
Osteoarthritis |
| Experiment: |
SA-β-gal activity assay//Telomerase activity assay |
| Description: |
To examine the effect of Rg3 on chondrocyte senescence, we measured SA-β-Gal activity 5 days after exposure of the cells to IL-1b, with or without Rg3, for 24 h.IL-1b stimulation resulted in a significant increase in the numbers of SA-β-Gal-positive cells in comparison with control cells treated with the vehicle alone. However, co-incubation with IL-1b and Rg3 significantly suppressed expression of the senescence marker.Rg3 at 1 and 2.5 lM significantly increased the telomerase activity of chondrocytes in comparison with IL-1b-treated cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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