External factors
| External factors: |
Gemcitabine |
| Category: |
Chemical compounds |
| Phenotype: |
Patients with pancreatic ductal adenocarcinoma |
| Tissue type: |
Tumor tissue |
| Cell name: |
Miapaca-2,PANC-1 |
| Experiment: |
SA-β-gal activity assay//qRT-PCR |
| Description: |
Gemcitabine efficiently induced senescence in Miapaca-2 and Panc-1 cells in a dose-dependent manner but not in L3.6 pl cells (data not shown), as evidenced by increased SA β-gal staining. Moreover, gemcitabine significantly increased the levels of senescence-associated molecules including P53, P21, P19, PML, and DCR2 in Miapaca-2 and Panc-1 cells, except P53 in Panc1 cells . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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