External factors
| External factors: |
Doxorubicin |
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experiment: |
SA-β-gal activity assay//Western blot//Flow cytometry//PI staining//ELISA |
| Description: |
On the 13th day the CHEMO-treated cells exhibited several features of senescence: flatten morphology , increased size and granularity , augmented SA-β-gal activity and polyploidization. Moreover, the elevated expression of DDR proteins: γ-H2A.X, p-p53, and p21, and geroconversion markers [7]: cyclin D1 and p-S6 was detectable. In addition, the cells up-regulated secretion of SASP factors: VEGF and IL-8 . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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