External factors
| External factors: |
Ethanol |
| Category: |
Chemical compounds |
| Phenotype: |
Atherosclerosis |
| Cell name: |
Endothelial cell |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Ethanol could decrease SA-β-gal positive cells in the plaque surface. Furthermore, to explore the effects of ethanol on endothelial cells, the ratio of Ac-p53/p16-to CD31-stained areas was assessed. The area ratios of Ac-p53/CD31 and p16/CD31 were significantly attenuated by ethanol, suggesting the inhibitory effects of ethanol on endothelial senescence. |
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Regulatory relationship
| R-EF-Target gene:
|
Activation |
| Official symbol(s): |
ALDH2 |
| Target gene experiment: |
Western blot |
| Target gene description: |
In addition, the 0.3 g/kg dose of ethanol increased the protein expression and activity of ALDH2, while the lower and higher doses had little effect .The 0.3 g/kg dose of ethanol also increased the ALDH2-positive staining area. These results indicate that the appropriate dose of ethanol promotes ALDH2 activation in the artery vessel wall. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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