External factors
| Category: |
Chemical compounds |
| Phenotype: |
Colorectal cancer |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
Interestingly, at 100 μM of MNNG treatment,the HCT-116 cells showed a major change in their cell cycle arrest profile in which the G0/G1 phase arrest was significantly increased, and the G2/M phase arrest was decreased as compared to control cells.Our result showed that senescence-associated β-galactosidase staining increased in cells treated with 100 μM MNNG as compared to untreated cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Target gene experiment: |
Western blot//Northern blot |
| Target gene description: |
After 50 h of treatment with MNNG, the APC mRNA levels decreased, which paralleled with the decreased levels of APC protein. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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