External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Flow cytometry |
| Description: |
SA-β-gal activity assay:SA-gal staining was significantly increased in the tBHPstimulated cells compared with the control cells. Flow cytometry:Flow cytometry was used to characterize the nature of cell cycle arrest. The cell cycle was arrested at the G0?G1 phase in the tBHP-stimulated cells (90.76% ± 6.34%) compared with the control cells. |
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Regulatory relationship
| Target gene:
|
BCL-2//BAX//STAT1//STAT3 |
| R-EF-Target gene:
|
Downregulation//Upregulation//Activation//Activation |
| Official symbol(s): |
BCL-2//BAX//STAT1//STAT3 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Bcl-2 protein expression decreased (p < 0.05) while Bax protein expression significantly increased (p < 0.01) in tBHP-induced cells compared with the control cells.Exposure of cells to 30 mol/L tBHP resulted in activation of STAT1 and STAT3 as manifested by an increase in STAT phosphorylation. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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