External factors
| Category: |
Chemical compounds |
| Experimental category: |
HL |
| Experiment: |
Flow cytometry//SA-β-gal activity assay |
| Description: |
JQ1-treated MM.1S cells revealed a pronounced decrease in the proportion of cells in S-phase, with a concomitant increase in cells arrested in G0/G1 ;Treatment with JQ1 resulted in pronounced cellular senescence by beta-galactosidase staining. |
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Regulatory relationship
| Target gene:
|
BET BROMODOMAIN |
| R-EF-Target gene:
|
Inhibition |
| Official symbol(s): |
BET BROMODOMAIN |
| Target gene experiment: |
Gene set enrichment analysis//Western blot//RT-PCR |
| Target gene description: |
Gene sets defined by adjacency to Myc-binding motifs were in almost all cases significantly enriched in JQ1-suppressed genes we studied the consequence of JQ1 treatment on the expression of 230 cancer-related genes in a human MM cell line (MM.1S),Downregulation of MYC was further confirmed by RT-PCR and immunoblot. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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