External factors
| External factors: |
Resveratrol |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Flow cytometry//Cell morphological analysis |
| Description: |
Thus, in both cell lines, resveratrol induced the growth arrest, showing prominent feature of stress-induced senescence—an increased SA-β-galactosidase activity. Moreover, many cells in both lines increased in size showing enlarged nuclei—the morphology typical for the senescent cells (not shown). |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
BRCA1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
In A549 cells, the total amount of BRCA1 protein detected by D-9 antibody slightly increased between 6 and 30 h of treatment. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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