External factors
| External factors: |
Resveratrol/quercetin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Senescence induction by Rsv plus Quer, measured by the activity of acidic β‐galactosidase, a biochemical marker for lysosome acidification,(40) was cooperative, since each treatment alone produced around 20% of SA‐β‐gal positive cells, whereas combination of Rsv and Quer induced staining in almost all cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Activation |
| Official symbol(s): |
CASPASE-3/7 |
| Target gene experiment: |
Annexin V binding assay//PI staining |
| Target gene description: |
Rsv (50 μM) increased caspase 3/7 activity after 48 h of treatment at an intensity similar to 50 μM etoposide, used as a positive control. Quer (100 μM) was unable to induce caspase 3/7 even at 72 h of treatment. Neither 10 μM Res nor 25 μM Quer alone were able to induce caspase 3/7 activation; however, a strong activation was observed with the cotreatment, suggesting a synergistic effect of these compounds in caspase 3/7 activation. |
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Aging network
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Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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