External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
H2O2 alone (not in combination with quercetin) promoted the expression of senescence-associated β-galactosidase activity in NIH 3T3 cells. |
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Regulatory relationship
| Target gene:
|
CAVEOLIN-1//P53 |
| R-EF-Target gene:
|
Activation//Activation |
| Official symbol(s): |
CAVEOLIN-1//P53 |
| Target gene experiment: |
Luciferase reporter assay |
| Target gene description: |
72 h after induction of oxidative stress with 150 μM H2O2, caveolin-1 promoter activity was increased by ~two fold.3 d after stimulation with H2O2(150 μM for 2 h), the p53 responsive element was activated by ~five- to sixfold. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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