External factors
| External factors: |
Ionizing radiation |
| Phenotype: |
Nasopharyngeal carcinoma |
| Experiment: |
MTS assay//Cell cycle analysis//SA-β-gal activity assay |
| Description: |
IR induced around 54% CNE2 cell senescence at 48 h,up to 79% at 72 h. Similar results were observed in U2OS cells. 6 Gy of IR induced 32% senescent cells at 48 h,up to 56% at 72 h ;The proliferation of CNE2-R cells was retarded compared to CNE2 cells, and more CNE2-R cells were arrested in G0/G1 phase than CNE2 cells.More β-Gal-positive cells were observed in CNE2-R cells than CNE2 cells. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
We observed that IR steadily elevated CDC6 protein levels 24, 48, and 72 h after IR exposure, though the cell proliferation was retarded. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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