External factors
| Phenotype: |
Dyskeratosis congenita |
| Cell name: |
F9-A353V,DC-C,DC-3,XDC1787-C,F26IIB |
| Experiment: |
SA-β-gal activity assay |
| Description: |
A fibroblastoid cell line established from a healthy relative of a DC patient (XDC-1787-C) was used as internal control. Expression of GSE4 and GSE24.2 significantly decreased cell senescence. |
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Regulatory relationship
| R-EF-Target gene:
|
Activation//Activation |
| Official symbol(s): |
C-MYC//TERT |
| Target gene experiment: |
Western blot |
| Target gene description: |
GSE4 and GSE4-NLS1 peptides showed similar capacity than GSE24.2 to activate c-myc and TERT promoters in the cell lines analyzed, including the F9-A353V mutant cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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