External factors
| Category: |
Chemical compounds |
| Experiment: |
Flow cytometry |
| Description: |
We demonstrated that the proportions of cells that progressed through the G0/G1into the S phase were increased by NS-398 compared with the controls. |
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Regulatory relationship
| Target gene:
|
COX-2//P53//PCNA//MMP1 |
| R-EF-Target gene:
|
Downregulation//Downregulation//--//Downregulation |
| Official symbol(s): |
COX2//P53//PCNA//MMP1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Treatment with NS-398 during replicative senescence inhibited the senescence-associated increase in COX-2 protein expression completely in the replicative senescent fibroblasts.NS-398 inhibited the senescence-associated increase in p53 expression during replicative senescence almost completely.NS-398 inhibited the senescence-associated decrease in PCNA protein expression during the replicative senescence of dermal fibroblasts.Treatment with NS-398 during replicative senescence decreased the senescence-associated increase in MMP-1 expression. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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