External factors
| External factors: |
PD0332991 |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
In addition, PD0332991-treated cells acquired senescent morphology, which became even more prominent when the drug was removed.In RPE cells,PD0332991 (a CDK 4/6 inhibitor) inhibited cell proliferation and resulted in the senescent morphology, typical for these cells.Senescent cells wereunable to proliferate following removal of PD0332991. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
383
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Official symbol(s): |
CYCLIN D1 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Most importantly, PD0332991 strongly induced cyclin D1. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793