External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay |
| Description: |
Indeed, treatment of cultured PC9 and H1975 cells with 3×mAbs induced prominent activity of SA‐β‐Gal. |
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Regulatory relationship
| Target gene:
|
DCR2//P16//P21//P27/KIP |
| R-EF-Target gene:
|
Upregulation//Upregulation//Upregulation//Upregulation |
| Official symbol(s): |
TNFRSF10D//P16//P21//P27/KIP |
| Target gene experiment: |
Western blot |
| Target gene description: |
Elevation of additional senescence markers was noted in vitro, such as DCR2 (TNFRSF10D) and several inhibitors of cyclin‐dependent kinases, namely p16, p21, and p27/KIP. |
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Aging network
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Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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