External factors
| External factors: |
Hecogenin |
| Category: |
Chemical compounds |
| Experiment: |
Flow cytometry//SA-β-gal activity assay |
| Description: |
At 50 μM, there was a small decrease in cells at S phase and a small increase in cells at G0/G1 and G2/M . This effect was enhanced with increased concentrations of hecogenin acetate. At 75 μM, 74% of cells were induced to cell cycle arrest in G0/G1 while 84.3 % of cells were induced to G0/G1 cell cycle arrest by hecogenin acetate 100 μM;Control cells showed only few SA-β-Gal staining spots, in contrast to cells treated with hecogenin acetate 50 μM where clusters of senescent cells were evident. |
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Regulatory relationship
| Target gene:
|
ERK1/2//MMP2 |
| Official symbol(s): |
ERK1/2//MMP2 |
| Target gene experiment: |
Western blot |
| Target gene description: |
Hecogenin acetate completely abolished ERK 1/2 phosphorylation induced by H2O2.Hecogenin acetate was able to inhibit the increase in MMP-2 content caused by H2O2 treatment. |
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Aging network
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Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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