External factors
| Category: |
Chemical compounds |
| Experiment: |
Cell morphological analysis//Flow cytometry |
| Description: |
As expected, progressive enlargement ofcellsizethatisoneofthetypicalsenescentphenotypes was clearly displayed .As expected, the intracellular ROS level increased continuously and the increased ROS was accompanied by the reduced ratio of GSH/GSSG, suggesting that oxidative stress was involved in the DFO-induced senescence. |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Target gene experiment: |
Western blot |
| Target gene description: |
Under exposure to DFO, expression level of Mfn2 protein increased transiently, but Fis1 protein was progressively decreased . |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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