External factors
| External factors: |
CS extract |
| Experimental category: |
HL |
| Experiment: |
SA-β-gal activity assay//Western blot//Cell Cell proliferation assay |
| Description: |
Furthermore,CSE treatment in control cells significantly increased GDF15 protein (up to 43-fold) and SA β-gal activity (up to 43% SA β-gal positive cells), inhibited cell proliferation (up to 54% decrease), and relocated HMGB1 protein from the intracellular milieu into the extracellular milieu. |
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Regulatory relationship
| Official symbol(s): |
GDF15 |
| Target gene experiment: |
SA-β-gal activity assay//Western blot//Cell proliferation assay |
| Target gene description: |
Disruption of GDF15 markedly reduced CSEinduced cellular senescence, represented by less induced SA β-gal activity, less inhibition of cell proliferation, and less HMGB1 release. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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