External factors
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//qRT-PCR//ELISA |
| Description: |
The pretreatment with CORM-A1 significantly alleviated the 5FU-elicited senescence of HUVECs. The CO treatment alone did not alter the basal senescence level of HUVECs, but reversed 5FU-induced endothelial senescence in a dose-dependent manner.5FU significantly increased PAI-1 and TNF-α expression, and the upregulation of these SASPs was attenuated by CO treatment. |
Warning: Undefined variable $target_genes in
/data/html/Aging-ReG/public/browse_detail_2.php on line
385
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
383
Regulatory relationship
| Target gene:
|
HO-1//ENOS//SIRT1 |
| R-EF-Target gene:
|
Upregulation//Upregulation//Upregulation |
| Official symbol(s): |
HMOX1//ENOS//SIRT1 |
| Target gene experiment: |
qRT-PCR//Western blot |
| Target gene description: |
5FU significantly decreased the HO-1 mRNA expression, whereas downregulation of HO-1 mRNA expression was enhanced by the CO treatment. 5FU significantly decreased eNOS and SIRT1 protein expression, whereas the downregulation of eNOS and SIRT1 protein expression was increased by the CORM-A1 treatment.The SIRT1 deficiency prevented CORM-A1 inhibition of 5FU-induced p21, PAI-1, TNF-α expression. |
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
471
Warning: Trying to access array offset on null in
/data/html/Aging-ReG/public/browse_detail_2.php on line
472
Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 751
Warning: Trying to access array offset on null in /data/html/Aging-ReG/public/browse_detail_2.php on line 754
Warning: Undefined variable $pathway_id in /data/html/Aging-ReG/public/browse_detail_2.php on line 793