External factors
| External factors: |
Homocysteine |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Western blot//qRT-PCR//Flow cytometry |
| Description: |
As expected, homocysteine could accelerate EC senescence when compared with standard conditions. Interestingly, homocysteine-increased p16, p21, and p53 expressions as well as SA-β-Gal positive cells, apoptosis cells, and cell cycle . |
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Regulatory relationship
| R-EF-Target gene:
|
Downregulation |
| Official symbol(s): |
HTERT |
| Target gene experiment: |
Western blot |
| Target gene description: |
Indeed, homocysteine also accelerated the reduction in hTERT mRNA and protein expression from P6 to P10. In addition, homocysteine decreased the expression of hTERT in a dose-dependent manner in P4-5 HUVECs. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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