External factors
| External factors: |
Ionizing radiation |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
In order to establish MCF7 cells as a model for irradiationinduced senescence, we investigated further senescence markers,in addition to the enlarged morphology and SA-β-galactosidase activity. |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
In addition to the established SASP factors, also expression of IkBζ, which was almost undetectable in control cells, was increased about 5-fold in senescent MCF7 cells. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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