External factors
| External factors: |
Bleomycin |
| Category: |
Chemical compounds |
| Experiment: |
SA-β-gal activity assay//Cell morphological analysis |
| Description: |
Bleomycin treatment induced the typical senescence alterations, including an enlarged morphology, increased SA-β-gal activity as well as a strong nuclear recruitment of pHP1c . |
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Regulatory relationship
| R-EF-Target gene:
|
Upregulation |
| Target gene experiment: |
qRT-PCR |
| Target gene description: |
Importantly, the expression of IkBζ was increased 3.6-fold, indicating that upregulation of IkBζ is independent of the senescence-inducing stimulus. |
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Aging network
Annotation:
The green line represents Upregulation.
The purple line represents Downregulation.
The orange line represents Activation.
The yellow line represents Inhibition.
The gray line represents Unclear.
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